Neural precursor cell apoptosis and glial tumorigenesis following transplacental ethyl-nitrosourea exposure
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چکیده
منابع مشابه
Strain- and age-dependent transplacental carcinogenesis by 1-ethyl-1-nitrosourea in inbred strains of mice.
Mice. The same strains were used in our previous studies of the teratogenic effects of ENU, i. and C57L/J. They were mated at approximately 10 weeks of age. The females were observed daily for vaginal plugs and palpated to determine preg nancy. The day that vaginal plugs were found was recorded as Day 0. Treatment Schedule and Observation Procedure. ENU was freshly prepared as a 1% solution in ...
متن کاملLow susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats.
The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a si...
متن کاملExpression of neuronal and glial markers in so-called oligodendroglial tumors induced by transplacental administration of ethyl-nitrosourea in the rat.
A series of 18 tumors with histological features of oligodendrogliomas, induced in the rat by means of transplacental ethyl-nitrosourea administration were studied for immunohistochemical demonstration of neuronal (synaptophysin and neurofilament protein) and glial (gliofibrillar acidic protein and vimentin) markers. Most of the tumors showed cells with strong positivity to synaptophysin and to...
متن کاملDNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Dideoxy chain-termination DNA sequencing was used to determine the specific DNA base changes induced after in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU) using the xanthine guanine phosphoribosyltransferase (gpt) gene as the genetic target. The resultant mutation spectra were compared with the levels of O6-alkylguanine and O4-alkylthymidine ...
متن کاملInduced by N-ethyl-N-nitrosourea
Phenotypic reversion of the rubber-band, muscledefective phenotype conferred by unc-93(e1500) was used to determine the utility of Nethyl-Nnitrosourea (ENU) as a mutagen for genetic research in Cuenmhabditis ekguns. In this system, ENU produces revertants at a frequency of 3 X equivalent to that of the commonly used mutagen, EMS. The gene identity of 154 ENU-induced revertants shows that the di...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2001
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1205024